特別講演会のお知らせ【2019.12.9 Prof. Stephen Michnick】(2019.11.26更新)
演題 | “A molecular spectroscopy of living cells to map genetic and environmental origins of disease traits to molecular mechanisms” |
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演者 | Prof. Stephen Michnick |
所属 | カナダ・モントリオール大学医学部 生化学&分子医学部門 |
日時 | 2019年12月9日 (月) 14:30 ~ |
場所 | 北海道大学 理学部本館N-308室 |
共催 | 生命分子化学セミナー,日本生化学会北海道支部,北海道大学物質科学フロンティアを開拓するAmbitiousリーダープログラム,フロンティア化学教育研究センター |
概要 | Variations in the genome sequences of individuals suffering from specific diseases provide clues for identifying genes that could be targets for drugs against the disease. Finding a good path to a drug target has not, however, proven easy or even possible for most diseases. We have recently discovered that a path from gene variation to potential drug targets can be determined by analyzing the dynamics of cellular protein interaction networks in response to stresses applied to a cell. We have developed reporter assays that allow us to simultaneously detect the dynamics of thousands of protein-protein interactions. We examine which protein-protein interactions change together under a series of chemically-induced perturbations. We demonstrate with the example of the biguanide antidiabetic drug metformin how we gain novel insight into a drugs mechanism of action. Surprisingly, we show that we can also predict in this way, genes whose DNA sequence variants increase or decrease susceptibilities to human diseases. |
連絡先 |
北海道大学大学院理学研究院化学部門 生物化学研究室 |
関連資料
講演ポスター【2019.12.9 Prof. Stephen Michnick】(163KB)